Lozance L A, Zafirovska K G, Bogdanovska S V, Zafirovski G J
Department of Nephrology, Faculty of Medicine, St. Cyril and Methodius, University of Skopje, R. Macedonia.
Ren Fail. 1994;16(4):525-34. doi: 10.3109/08860229409045083.
We present a case of an extremely rare form of Ewing sarcoma--primary disseminated, with fulminating course, severe hypercalcemia, extensive calcium deposition in parenchymatous organs, including kidneys, and acute renal failure as a clinical consequence. Correction of hypercalcemia was followed by prompt restoration of the glomerular filtration rate (GFR), suggesting that hypercalcemia had a direct effect on its regulation independent of the renal tubular damage. The effectiveness of the treatment with indomethacin indirectly supports the possibility of prostaglandin-mediated humoral hypercalcemia of malignancy.
我们报告一例极其罕见的尤因肉瘤——原发性播散型，病程凶险，伴有严重高钙血症，实质器官包括肾脏有广泛钙沉积，并导致急性肾衰竭。高钙血症得到纠正后，肾小球滤过率（GFR）迅速恢复，这表明高钙血症对其调节有直接影响，与肾小管损伤无关。吲哚美辛治疗的有效性间接支持了前列腺素介导的恶性肿瘤体液性高钙血症的可能性。
