药物滥用与氯氮平治疗
Substance abuse and clozapine treatment.
作者信息
Buckley P, Thompson P A, Way L, Meltzer H Y
机构信息
Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
出版信息
J Clin Psychiatry. 1994 Sep;55 Suppl B:114-6.
PMID:7961553
Abstract
Among 118 patients with DSM-III-R diagnoses of schizophrenia or schizoaffective disorder who received treatment with clozapine, 29 patients had an antecedent or current history of substance abuse. Substance abusers and nonabusers showed similar improvements on measures of psychopathology and psychosocial functioning after 6 months of clozapine therapy. The implications of this finding are discussed.
摘要
在118例接受氯氮平治疗的DSM-III-R诊断为精神分裂症或分裂情感性障碍的患者中，29例患者有既往或当前药物滥用史。在氯氮平治疗6个月后，药物滥用者和非滥用者在精神病理学和心理社会功能测量方面显示出相似的改善。本文讨论了这一发现的意义。
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