[Nausea and vomiting in cytostatic therapy of melanoma patients with the use of metoclopramide and corticosteroid or ondansetron].

Nausea and vomiting develop during surgery, radio- and/or chemotherapy of malignant diseases. Several drugs belonging to different groups of compounds have been used against them in a large scale. After listing these drugs the authors explained their results. Between January 1992 and 1993, 40 chemotherapy-native melanoma patients were treated by emetogen chemotherapy. The incidence, the time-relationship and the number of nausea and vomiting were investigated during the first chemotherapy course. In the second part of the study ondansetron was applied to 50 patients having developed nausea and vomiting in earlier chemotherapy. When using metoclopramide and corticosteroid during the chemotherapy nausea and vomiting developed in 9 (22.5%) and 20 (50%) cases. Nausea 8/50 (11.25%) was observed with the application of Zofran p. o. while vomiting did not develop. Delayed emesis has not been seen during the antiemetic therapies. The laboratory parameters were within the normal range.