Seiler C A, Renner E L, Horber F, Rieder H, Reichen J, Czerniak A
Klinik für Viszerale und Transplantationschirurgie, Inselspital Bern.
Schweiz Med Wochenschr. 1994 Nov 26;124(47):2123-30.
Today, orthotopic liver transplantation is the treatment of choice for the endstage of various liver diseases, and a 1-year survival rate of over 80% is reported in international surveys. The liver transplant program of the Inselspital is very small compared to international centers and this may raise questions about the results and the justification for such a program. In a 24-month period, 20 liver transplants (including 2 retransplants) have been performed in 18 patients at the Inselspital. 2 patients (11%) died 20 and 268 days respectively after transplantation. 2 patients (11%) had significant morbidity 502 and 529 days respectively after transplantation. After a median follow-up of 11.5 months postoperatively, 14 (80% of all patients) lived an independent life. 9 (50%) were fully reintegrated in the household or in their profession and 5 others (30%) were working part time. We conclude that even a small liver transplant program based only on routine resources can achieve results comparable to international standards.
如今,原位肝移植是各种肝病终末期的首选治疗方法,国际调查显示其1年生存率超过80%。与国际中心相比,因塞尔医院的肝移植项目规模很小,这可能会让人对该项目的结果以及开展该项目的合理性产生疑问。在24个月的时间里,因塞尔医院为18名患者进行了20例肝移植手术(包括2例再次移植)。2例患者(11%)分别在移植后20天和268天死亡。2例患者(11%)分别在移植后502天和529天出现严重并发症。术后中位随访11.5个月时,14名患者(占所有患者的80%)能够独立生活。9名患者(50%)完全重新融入家庭或恢复工作,另外5名患者(30%)从事兼职工作。我们得出结论,即使是一个仅基于常规资源的小型肝移植项目,也能取得与国际标准相当的结果。