促甲状腺激素释放激素的强效类似物YM-14673对共济失调突变小鼠的共济失调改善作用
Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice.
作者信息
Matsui K, Wada K, Kwak S
机构信息
National Institute of Neuroscience, NCNP, Tokyo, Japan.
出版信息
Eur J Pharmacol. 1994 Mar 21;254(3):295-7. doi: 10.1016/0014-2999(94)90469-3.
The effects of YM-14673 (N alpha-[[(S)-4-oxo-2-azetidinyl]carbonyl]- L-histidyl-L-prolinamide dihydrate), a potent analog of thyrotropin releasing hormone (TRH), on the behavior of ataxic mutant mice (staggerer, realer, Purkinje cell degeneration and weaver mice) were investigated in comparison with those of TRH in an open-field apparatus. The fall index, the ratio of the number of falls to the distance moved, was defined as an index for ataxia. YM-14673 reduced the fall index in all types of ataxic mice examined and was more potent than TRH in reeler, staggerer and Purkinje cell degereration mice. YM-14673 may have a beneficial effect on patients with spinocerebellar degeneration.
研究了促甲状腺激素释放激素（TRH）的强效类似物YM-14673（Nα-[[(S)-4-氧代-2-氮杂环丁烷基]羰基]-L-组氨酰-L-脯氨酰胺二水合物）在旷场实验装置中对共济失调突变小鼠（蹒跚鼠、摇摆鼠、浦肯野细胞变性小鼠和织工鼠）行为的影响，并与TRH进行了比较。跌倒指数定义为跌倒次数与移动距离的比值，作为共济失调的指标。YM-14673降低了所有受试共济失调小鼠的跌倒指数，并且在摇摆鼠、蹒跚鼠和浦肯野细胞变性小鼠中比TRH更有效。YM-14673可能对脊髓小脑变性患者有有益作用。
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