类风湿关节炎患者血浆及尿液中β2微球蛋白水平
Plasma and urinary levels of beta2 microglobulin in rheumatoid arthritis.
作者信息
Manicourt D, Brauman H, Orloff S
出版信息
Ann Rheum Dis. 1978 Aug;37(4):328-32. doi: 10.1136/ard.37.4.328.
Abstract
Plasma and urinary levels of beta2 microglobulin have been investigated in 21 patients suffering from rheumatoid arthritis (RA). Despite a normal renal glomerular function in all patients 50% of them had supranormal plasma beta2 microglobulin levels and 30% had a higher than normal urinary output of beta2 microglobulin generally related to the high plasma level. Plasma beta2 microglobulin levels paralleled closely the lymphocytosis and the 'joint count' both indexes of the severity of the disease. beta2 Microglobulin was normally secreted by the lymphoid tissue and it is suggested that it reflects the increase of the total mass and/or membrane turnover of the lymphoid tissue in RA. beta2 Microglobulin may be considered as a good parameter of the degree of severity of the joint and extra-articular involvement as well as a useful tool for the evaluation of drug efficacy in rheumatoid arthritis.
摘要
对21例类风湿性关节炎（RA）患者的血浆和尿液中β2微球蛋白水平进行了研究。尽管所有患者的肾小球功能均正常，但其中50%的患者血浆β2微球蛋白水平超常，30%的患者β2微球蛋白尿排出量高于正常，这通常与血浆中该物质的高水平有关。血浆β2微球蛋白水平与淋巴细胞增多以及“关节计数”密切相关，这两个指标都是疾病严重程度的指标。β2微球蛋白通常由淋巴组织分泌，有人认为它反映了类风湿性关节炎中淋巴组织总体质量和/或膜更新的增加。β2微球蛋白可被视为关节和关节外受累严重程度的良好参数，也是评估类风湿性关节炎药物疗效的有用工具。
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