Golub M S, Takeuchi P T, Keen C L, Gershwin M E, Hendrickx A G, Lonnerdal B
Department of Internal Medicine, School of Medicine, University of California, Davis.
Am J Clin Nutr. 1994 Aug;60(2):238-43. doi: 10.1093/ajcn/60.2.238.
Young rhesus monkeys (Macaca mulatta, n = 14) 25-30 mo of age were fed a zinc-deficient (ZD) diet (2 micrograms Zn/g diet) (moderate zinc deprivation) over 15 week. The ZD diet period was compared with a zinc-adequate (ZA) diet period (50 micrograms Zn/g diet) of the same duration, which either preceded or followed it (crossover design). Plasma zinc was lower at the end of the ZD than after the ZA period. There were no overt signs of zinc deficiency or effects on growth rate. Spontaneous motor activity was lower and performance of a visual-attention task and short-term-memory task were poorer during the ZD period than during the ZA period. Behavioral effects were detected as changes from individual baseline values, and often represented a failure to improve. The results suggests that dietary zinc deprivation can modulate behavior in prepubertal monkeys without affecting growth.
25至30月龄的幼年恒河猴（猕猴，n = 14）被喂食锌缺乏（ZD）饮食（每克饮食含2微克锌）（中度锌剥夺），持续15周。将ZD饮食期与相同持续时间的锌充足（ZA）饮食期（每克饮食含50微克锌）进行比较，ZA饮食期在ZD饮食期之前或之后（交叉设计）。ZD饮食期结束时血浆锌低于ZA饮食期之后。没有明显的锌缺乏迹象或对生长速率的影响。在ZD饮食期，自发运动活动较低，视觉注意力任务和短期记忆任务的表现比ZA饮食期差。行为影响被检测为个体基线值的变化，且通常表现为没有改善。结果表明，饮食锌剥夺可调节青春期前猴子的行为而不影响生长。
