Miller J A
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706.
Chem Biol Interact. 1994 Jun;92(1-3):329-41. doi: 10.1016/0009-2797(94)90074-4.
Many laboratories have characterized the electrophilic metabolites of chemical carcinogens and their covalently bound adducts with genomic DNA in vivo. Recent studies from our laboratory have shown that enzymatic sulfonation of members of several classes of proximate carcinogens containing C- or N-hydroxy groups converts them to electrophilic, mutagenic, and carcinogenic sulfuric acid ester metabolites in mouse liver. These compounds form the subject of this report.
许多实验室已对化学致癌物的亲电代谢产物及其在体内与基因组DNA的共价结合加合物进行了表征。我们实验室最近的研究表明，几类含有C-或N-羟基的近致癌物的酶促磺化作用会将它们转化为小鼠肝脏中的亲电、诱变和致癌硫酸酯代谢产物。这些化合物构成本报告的主题。
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