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[继发性免疫缺陷在急性痢疾病程迁延发展中的作用]

[The role of secondary immunodeficiencies in the development of a protracted course of acute dysentery].

作者信息

Usychenko E M, Mashilov V P

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1993 Mar-Apr(2):111-3.

PMID:8059562
Abstract

An opinion on the expediency of working out criteria for dividing acute dysentery patients into risk groups, depending on the development of immune deficiency, has been put forward. The results of the study of some characteristics of T-cell immunity system in 228 acute dysentery patients in relation to their clinical state are presented. Measurements of total active T lymphocytes, T helpers and T suppressors have been made. Disturbances in the immunity characteristics under study, more pronounced in patients with a more severe and prolonged course of the disease, as well as in patients receiving belated treatment, have been noted. Besides the total number of T lymphocytes and their subpopulations, the imbalance of these cells is also an important feature. To solve the problem of prescribing immunocorrective therapy, not only immunological, but also clinical characteristics should be taken into consideration.

摘要

有人提出了一种观点,即根据免疫缺陷的发展情况制定将急性痢疾患者分为危险组的标准是否合理。本文介绍了对228例急性痢疾患者T细胞免疫系统的一些特征与其临床状态关系的研究结果。已对总活性T淋巴细胞、T辅助细胞和T抑制细胞进行了测量。研究发现,在病情更严重、病程更长的患者以及接受延迟治疗的患者中,所研究的免疫特征紊乱更为明显。除了T淋巴细胞及其亚群的总数外,这些细胞的失衡也是一个重要特征。为了解决免疫纠正治疗的处方问题,不仅应考虑免疫学特征,还应考虑临床特征。

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