Bove M, Massobrio G, Martinoia S, Grattarola M
Department of Biophysical and Electronic Engineering (DIBE), University of Genoa, Italy.
Biol Cybern. 1994;71(2):137-45. doi: 10.1007/BF00197316.
This paper describes an ad hoc modified version of the electrical circuit analysis program SPICE, which has been optimized for detailed simulations of the behaviour of neurons. An equivalent-circuit description of the simulation building blocks is provided, and the SPICE modifications are specified. These modifications, in contrast to previous uses of SPICE, allows one to simulate the behaviour of neurons of Hodgkin-Huxley type (excitable membrane) and of postsynaptic membranes without any approximations. Simulation results are reported and compared, both with data previously analysed in the literature by other authors and with experimental data recently obtained by coupling neurons to planar extracellular microelectrodes. Details of the circuit elements used in the simulations are reported. The improvements of our proposed model are discussed in comparison with a previous SPICE-based model described in the literature.
本文描述了电路分析程序SPICE的一个临时修改版本，该版本已针对神经元行为的详细模拟进行了优化。提供了模拟构建模块的等效电路描述，并指定了对SPICE的修改。与之前对SPICE的使用不同，这些修改使人们能够在没有任何近似的情况下模拟霍奇金-赫胥黎类型（可兴奋膜）的神经元和突触后膜的行为。报告了模拟结果，并将其与其他作者先前在文献中分析的数据以及最近通过将神经元与平面细胞外微电极耦合获得的实验数据进行了比较。报告了模拟中使用的电路元件的详细信息。与文献中描述的基于SPICE的先前模型相比，讨论了我们提出的模型的改进之处。
