朗格汉斯细胞组织细胞增多症中的单克隆抗体疗法——可行且合理吗？
Monoclonal antibody therapy in Langerhans cell histiocytosis--feasible and reasonable?
作者信息
Kelly K M, Pritchard J
机构信息
Division of Hematology/Oncology, Children's Hospital of Philadelphia, PA 19104.
出版信息
Br J Cancer Suppl. 1994 Sep;23:S54-5.
Abstract
Many recent studies have demonstrated the range of disorders in which monoclonal antibodies have a clinical role. The monoclonal antibody NA1/34, directed against a surface antigen present on lesional cells ('LCH cells'), has been found to localise in vivo to sites of disease. This review explores the possible applications and limitations of monoclonal antibody based-therapy in Langerhans cell histiocytosis.
摘要
许多近期研究已证明单克隆抗体在一系列疾病中具有临床作用。针对病变细胞（“朗格汉斯细胞组织细胞增多症细胞”）上存在的一种表面抗原的单克隆抗体NA1/34，已被发现在体内可定位于疾病部位。本综述探讨了基于单克隆抗体的疗法在朗格汉斯细胞组织细胞增多症中的可能应用及局限性。
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