在一种扇蟹（铜铸熟若蟹）中出现石房蛤毒素和新石房蛤毒素的氨基甲酰 -N-羟基衍生物。

Occurrence of carbamoyl-N-hydroxy derivatives of saxitoxin and neosaxitoxin in a xanthid crab Zosimus aeneus.

作者信息

Arakawa O, Noguchi T, Shida Y, Onoue Y

机构信息

Laboratory of Marine Botany and Environmental Science, Faculty of Fisheries, Kagoshima University, Japan.

出版信息

Toxicon. 1994 Feb;32(2):175-83. doi: 10.1016/0041-0101(94)90106-6.

DOI:10.1016/0041-0101(94)90106-6

PMID:8153956

Abstract

Two novel paralytic toxins were isolated from toxic specimens of a xanthid crab Zosimus aeneus inhabiting Ishigaki Island, Okinawa. The structures of two of these were deduced to be carbamoyl-N-hydroxysaxitoxin and carbamoyl-N-hydroxyneosaxitoxin based on electrophoresis, high performance liquid chromatography, electrospray ionization mass spectrometry, 1H NMR, 13C NMR and conversion experiments. They showed specific toxicities of 1700 and 1400 mouse units per mg on i.p. injection into mice.

摘要

从栖息于冲绳石垣岛的一种扇蟹（花纹爱洁蟹）的有毒标本中分离出两种新型麻痹毒素。基于电泳、高效液相色谱、电喷雾电离质谱、1H核磁共振、13C核磁共振和转化实验，推断其中两种的结构为氨基甲酰基-N-羟基石房蛤毒素和氨基甲酰基-N-羟基新石房蛤毒素。经腹腔注射到小鼠体内后，它们的比毒性分别为每毫克1700和1400小鼠单位。