编码A15、L6和S5.7（TAPA1）的三个人类基因的染色体定位：均为跨膜4蛋白超家族的成员。

Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins.

作者信息

Virtaneva K I, Emi N, Marken J S, Aruffo A, Jones C, Spurr N K, Schröder J P

机构信息

Department of Genetics, University of Helsinki, Finland.

出版信息

Immunogenetics. 1994;39(5):329-34. doi: 10.1007/BF00189229.

DOI:10.1007/BF00189229

PMID:8168850

Abstract

The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome, and myotonic dystrophy. The L6 antigen is mainly expressed in lung, breast, colon, ovarian carcinomas, and healthy epithelial tissue in humans. The S5.7(TAPA1) antigen is expressed in most human cell lines and is shown to be associated with B-cell surface molecules CD19 and Leu-13. In this study we have used interspecies specific somatic cell hybrids and human-specific cDNA probes to localize the A15 (MXS1), L6 (M3S1), and TAPA1 genes to Xq11, 3q21-25, and 11p15.5, respectively.

摘要

A15、L6和S5.7（TAPA1）蛋白是跨膜4超家族（TM4SF）的成员。A15在未成熟的人类T细胞和人脑中表达。编码A15的MXS1（CCG - B7）基因含有三联体核苷酸重复序列，这些序列与神经精神疾病如亨廷顿舞蹈症、脆性X综合征和强直性肌营养不良有关。L6抗原主要在人类的肺、乳腺、结肠、卵巢癌以及健康上皮组织中表达。S5.7（TAPA1）抗原在大多数人类细胞系中表达，并显示与B细胞表面分子CD19和Leu - 13相关。在本研究中，我们使用种间特异性体细胞杂种和人类特异性cDNA探针，分别将A15（MXS1）、L6（M3S1）和TAPA1基因定位到Xq11、3q21 - 25和11p15.5。