氟马西尼对静脉注射咪达唑仑后恢复情况的影响。

Effect of flumazenil on the recovery from intravenous midazolam.

作者信息

Hunter K M, Zacharias M, Parkinson R, Luyk N H

机构信息

Department of Oral Medicine and Oral Surgery, School of Dentistry, University of Otago, Dunedin.

出版信息

N Z Dent J. 1994 Mar;90(399):9-12.

PMID:8190388

Abstract

Psychomotor recovery characteristics were studied in young, healthy patients undergoing intravenous sedation using midazolam for the extraction of third molars. There were significant changes to Choice Reaction Time and Critical Flicker Fusion Threshold noted half an hour after the administration of midazolam (P < 0.001). The administration of the benzodiazepine antagonist flumazenil significantly improved the Choice Reaction Times, but failed to reverse changes in Critical Flicker Fusion Threshold up to 120 minutes later. However, the use of flumazenil assured that no post-operative changes in oxygen saturation occurred in any of the patients.

摘要

对使用咪达唑仑进行静脉镇静以拔除第三磨牙的年轻健康患者的精神运动恢复特征进行了研究。在给予咪达唑仑半小时后，选择反应时间和临界闪烁融合阈值有显著变化（P < 0.001）。给予苯二氮䓬拮抗剂氟马西尼可显著改善选择反应时间，但在120分钟后仍未能逆转临界闪烁融合阈值的变化。然而，使用氟马西尼确保了所有患者术后血氧饱和度均未发生变化。