Dwyer C M, Chapman R S, Smith G D
Department of Dermatology, Stobhill General Hospital, Glasgow, UK.
Dermatology. 1994;188(4):326-8. doi: 10.1159/000247177.
An 83-year-old man had the typical cutaneous features of papuloerythroderma of Ofuji. There were reduced numbers of lymphocytes and platelets in his peripheral blood but the eosinophil count was normal. Skin biopsy showed a nondiagnostic infiltrate of T lymphocytes in the dermis. Treatment with topical steroids and UVB phototherapy was ineffective. Twelve months after presentation, a further skin biopsy revealed atypical lymphoid cells invading the epidermis and the skin adnexae. A diagnosis of malignant lymphoma was made; no evidence of extracutaneous spread was found. Photochemotherapy produced rapid resolution of the skin eruption and clearance of the cutaneous infiltrate. Papuloerythroderma may be a manifestation of a cutaneous lymphoma.
一名83岁男性具有典型的Ofuji红皮病丘疹型皮肤表现。其外周血淋巴细胞和血小板数量减少，但嗜酸性粒细胞计数正常。皮肤活检显示真皮层有T淋巴细胞浸润，但无法确诊。外用类固醇和紫外线B光疗无效。就诊12个月后，再次进行皮肤活检发现非典型淋巴细胞侵入表皮和皮肤附属器。诊断为恶性淋巴瘤；未发现皮肤外扩散的证据。光化学疗法使皮疹迅速消退，皮肤浸润消失。红皮病丘疹型可能是皮肤淋巴瘤的一种表现。
