两种六氯联苯对N-甲酰甲硫氨酰亮氨酰苯丙氨酸和佛波酯肉豆蔻酸酯刺激的多形核白细胞产生超氧化物的影响差异。
Differences in the effects of two hexachlorobiphenyls on superoxide generation by polymorphonuclear leucocytes stimulated by N-formyl-methionyl-leucyl-phenylalanine and phorbol myristate acetate.
作者信息
Iwata M, Nishihara Y, Watanabe Y, Miyahara M, Saeki K
机构信息
Department of Pharmacology, Okayama University Medical School, Japan.
出版信息
Occup Environ Med. 1994 Apr;51(4):271-4. doi: 10.1136/oem.51.4.271.
Abstract
The effects of hexachlorobiphenyls (HCBs) on superoxide (O2-) generation by guinea pig polymorphonuclear leucocytes were examined. 2,3,6,2',3',6'-HCB by itself had only a weak inductive effect on O2- generation. This compound, however, enhanced O2- generation stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) about twofold, but not the generation induced by phorbol myristate acetate (PMA). On the other hand, 3,4,5,3',4',5'-HCB suppressed O2- generation stimulated by both FMLP and PMA. The inhibitory potency of this compound was far greater with PMA (ID50, 5 microM) than with FMLP (ID50, 40 microM).
摘要
研究了六氯联苯（HCBs）对豚鼠多形核白细胞产生超氧化物（O2-）的影响。2,3,6,2',3',6'-六氯联苯本身对O2-的产生只有微弱的诱导作用。然而，该化合物能使N-甲酰甲硫氨酰亮氨酰苯丙氨酸（FMLP）刺激产生的O2-增加约两倍，但对佛波酯（PMA）诱导的O2-产生没有影响。另一方面，3,4,5,3',4',5'-六氯联苯抑制了FMLP和PMA刺激产生的O2-。该化合物对PMA（半数抑制浓度，5 microM）的抑制效力远大于对FMLP（半数抑制浓度，40 microM）的抑制效力。
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引用本文的文献
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Differences in the effects of two hexa-chlorophenols on superoxide generation by polymorphonuclear leucocytes stimulated by N-formyl-methionyl-leucyl-phenylalanine and phorbol myristate acetate.两种六氯酚对N-甲酰甲硫氨酰亮氨酰苯丙氨酸和佛波酯肉豆蔻酸酯刺激的多形核白细胞产生超氧化物的影响差异。
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