饮用高硝酸盐含量的水会导致甲状腺肿大。
Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid.
作者信息
van Maanen J M, van Dijk A, Mulder K, de Baets M H, Menheere P C, van der Heide D, Mertens P L, Kleinjans J C
机构信息
Department of Health Risk Analysis and Toxicology, University of Limburg, Maastricht, The Netherlands.
出版信息
Toxicol Lett. 1994 Jun;72(1-3):365-74. doi: 10.1016/0378-4274(94)90050-7.
We studied the effect of nitrate contamination of drinking water on volume and function of the thyroid in human populations exposed to different nitrate levels in their drinking water. Two sets of low and medium (tap) water, respectively medium and high (well) water nitrate exposure groups were compared. Drinking of nitrate-contaminated water was dose-dependently related with 24-h urinary nitrate excretion and salivary nitrate levels. No iodine deficiency was observed in any of the nitrate exposure groups. A dose-dependent difference in the volume of the thyroid was observed between low and medium vs. high nitrate exposure groups, showing development of hypertrophy at nitrate levels exceeding 50 mg/l. An inverse relationship was established between the volume of the thyroid and serum thyroid stimulating hormone (TSH) levels.
我们研究了饮用水硝酸盐污染对饮用水中硝酸盐水平不同的人群甲状腺体积和功能的影响。比较了两组分别为低和中（自来水）水、中高（井水）水硝酸盐暴露组。饮用硝酸盐污染水与24小时尿硝酸盐排泄和唾液硝酸盐水平呈剂量依赖性相关。在任何硝酸盐暴露组中均未观察到碘缺乏。低、中硝酸盐暴露组与高硝酸盐暴露组之间甲状腺体积存在剂量依赖性差异，表明在硝酸盐水平超过50mg/l时会出现甲状腺肥大。甲状腺体积与血清促甲状腺激素（TSH）水平之间建立了负相关关系。
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