Zucali R, Merson M, Placucci M, Di Palma S, Veronesi U
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
Radiother Oncol. 1994 Mar;30(3):271-3. doi: 10.1016/0167-8140(94)90469-3.
At Istituto Tumori of Milano in a series of 3295 patients treated with conservative surgery and radiotherapy for breast cancer from 1973 to 1989 three cases of soft tissue sarcoma were observed in irradiated breasts. One patient developed a fibrosarcoma of the breast stroma, 16 months after irradiation. A grade II bulky angiosarcoma was diagnosed in the breast of a patient treated 59 months previously. The third was a grade II angiosarcoma detected 41 months after therapy. At present, the risk of a second primary in the irradiated breast seems too low to justify modification of our present policy of conservative therapy of breast cancer, but a careful and longer follow-up is needed.
在米兰肿瘤研究所，1973年至1989年期间对3295例乳腺癌患者进行了保守手术和放疗，在接受放疗的乳房中观察到3例软组织肉瘤。1例患者在放疗后16个月发生了乳腺间质纤维肉瘤。1例患者在59个月前接受治疗后，其乳房被诊断为II级巨大血管肉瘤。第3例是在治疗后41个月检测到的II级血管肉瘤。目前，放疗乳房中发生第二原发性肿瘤的风险似乎过低，不足以证明改变我们目前乳腺癌保守治疗策略的合理性，但需要进行更仔细、更长时间的随访。
