肌动蛋白解聚因子化学感应神经元在秀丽隐杆线虫滞育形成行为中的作用。
A role of ADF chemosensory neurones in dauer formation behaviour in C. elegans.
作者信息
Shakir M A, Miwa J, Siddiqui S S
机构信息
Laboratory of Molecular Biology, Toyohashi University of Technology, Japan.
出版信息
Neuroreport. 1993 Sep 3;4(10):1151-4.
In Caenorhabditis elegans, mutants in osmotic avoidance behaviour (osm), which fail to avoid high concentrations of salts and sugars, have been previously identified. These osm mutants are also defective in dauer larva formation, and fail to take up fluorescein dye in six pairs of amphid neurones (ADF, ADL, ASH, ASI, ASJ, and ASK) and two pairs of phasmid neurones. Analysis of the FITC dye uptake by osm-3 mutants show that seven of the eight osm-3 alleles can take up FITC dyes in one pair of amphid neurones, ADF. Comparison of dauer larva formation behaviour in different osm-3 alleles shows a direct correlation between improved behaviour and FITC dye uptake. Therefore, these allelic strains are useful in defining the role of ADF neurones in dauer larva formation.
在秀丽隐杆线虫中，先前已鉴定出在渗透回避行为（osm）方面存在缺陷的突变体，这些突变体无法避开高浓度的盐和糖。这些osm突变体在 dauer 幼虫形成方面也存在缺陷，并且在六对化感器神经元（ADF、ADL、ASH、ASI、ASJ 和 ASK）和两对尾感器神经元中无法摄取荧光素染料。对 osm-3 突变体摄取 FITC 染料的分析表明，八个 osm-3 等位基因中的七个可以在一对化感器神经元 ADF 中摄取 FITC 染料。不同 osm-3 等位基因中 dauer 幼虫形成行为的比较表明，行为改善与 FITC 染料摄取之间存在直接相关性。因此，这些等位基因菌株有助于确定 ADF 神经元在 dauer 幼虫形成中的作用。
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