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4-酰氨基-4-脱氧-4'-去甲基表鬼臼毒素类似物的合成及其抗肿瘤活性

[Synthesis and antitumor activities of 4-acylamido-4-deoxy-4'-demethylepipodophyllotoxin analogues].

作者信息

Wang Z G, Yin S F, Ma W Y, Li B S, Zhang C N

机构信息

Shanghai Institute of Pharmaceutical Industry.

出版信息

Yao Xue Xue Bao. 1993;28(6):422-7.

PMID:8249599
Abstract

Twenty four 4-acylamidc-4-deoxy-4'-demethylepipodophyllotoxins were synthesized by acylation of 4-amino-4-deoxy-4'-demethylepipodophyllotoxin by means of usual methods, and screened in vitro. This type of compounds showed strong antitumor activities, most of them are superior to etoposide in the inhibition against L1210 and KB cells.

摘要

通过常规方法用4-氨基-4-脱氧-4'-去甲基表鬼臼毒素进行酰化反应合成了24种4-酰氨基-4-脱氧-4'-去甲基表鬼臼毒素，并进行了体外筛选。这类化合物显示出很强的抗肿瘤活性，其中大多数在抑制L1210和KB细胞方面优于依托泊苷。

相似文献

1
[Synthesis and antitumor activities of 4-acylamido-4-deoxy-4'-demethylepipodophyllotoxin analogues].4-酰氨基-4-脱氧-4'-去甲基表鬼臼毒素类似物的合成及其抗肿瘤活性
Yao Xue Xue Bao. 1993;28(6):422-7.
2
[Synthesis and antitumor activity of 4-(2-amido-2-ethoxycarbonyl) ethylsulfenyl-4-deoxy-4'-demethylepipodophyllotoxin analogues].
Yao Xue Xue Bao. 1993;28(9):668-72.
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[Synthesis and antitumor activities of 4-acylthiol-4-deoxy-4'-demethylepipodophyllotoxin analogues].4-酰硫基-4-脱氧-4'-去甲基表鬼臼毒素类似物的合成及其抗肿瘤活性
Yao Xue Xue Bao. 1992;27(5):345-8.
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[Synthesis and antitumor activity of 4-alkylthio-4-deoxy-4'-demethylepipodophyllotxin derivatives].
Yao Xue Xue Bao. 1992;27(9):656-61.
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[Synthesis and activities of 4-deoxy-4 beta-arylmehtylene sulfonylamido-4'-demethylpodophyllotoxins].[4-脱氧-4β-芳基亚甲基磺酰氨基-4'-去甲基鬼臼毒素的合成与活性]
Yao Xue Xue Bao. 2001 Feb;36(2):105-7.
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[Synthesis and antitumor activity of 4-S-(5-amido-1,3,4-thiodiazol-2-yl)4-deoxy-4'-demethylepipodophyllotoxi n analogues].
Yao Xue Xue Bao. 1993;28(10):762-5.
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[Synthesis and antitumor activity of 4-O-(halogenated) acyl-4'-demethylepipodophyllotoxin analogues].
Yao Xue Xue Bao. 1993;28(10):758-61.
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[Synthesis of spin labeled analogue of podophyllotoxin glycoside].[鬼臼毒素糖苷自旋标记类似物的合成]
Yao Xue Xue Bao. 1998 Dec;33(12):948-50.
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Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.
J Med Chem. 1998 Nov 5;41(23):4475-85. doi: 10.1021/jm9800752.
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Synthesis and cytotoxicity of racemic isodeoxypodophyllotoxin analogues with isoprene-derived side chains.具有异戊二烯衍生侧链的外消旋异去氧鬼臼毒素类似物的合成与细胞毒性
J Nat Prod. 2006 Aug;69(8):1145-52. doi: 10.1021/np050547x.

引用本文的文献

1
Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.基于结构的哌嗪连接双表鬼臼毒素依托泊苷类似物的设计、合成及生物学测试
Bioorg Med Chem. 2015 Jul 1;23(13):3542-51. doi: 10.1016/j.bmc.2015.04.022. Epub 2015 Apr 16.
2
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.依托泊苷类似物表鬼臼毒素-N-芥子气杂合化合物的基于结构的设计、合成及生物学测试，该化合物旨在与拓扑异构酶II和DNA共价结合。
Bioorg Med Chem. 2014 Nov 1;22(21):5935-49. doi: 10.1016/j.bmc.2014.09.014. Epub 2014 Sep 16.
3
Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents.
C-4修饰的鬼臼毒素类似物作为强效抗肿瘤药物的最新进展。
Med Res Rev. 2015 Jan;35(1):1-62. doi: 10.1002/med.21319. Epub 2014 May 14.