4-酰氨基-4-脱氧-4'-去甲基表鬼臼毒素类似物的合成及其抗肿瘤活性
[Synthesis and antitumor activities of 4-acylamido-4-deoxy-4'-demethylepipodophyllotoxin analogues].
作者信息
Wang Z G, Yin S F, Ma W Y, Li B S, Zhang C N
机构信息
Shanghai Institute of Pharmaceutical Industry.
出版信息
Yao Xue Xue Bao. 1993;28(6):422-7.
PMID:8249599
Abstract
Twenty four 4-acylamidc-4-deoxy-4'-demethylepipodophyllotoxins were synthesized by acylation of 4-amino-4-deoxy-4'-demethylepipodophyllotoxin by means of usual methods, and screened in vitro. This type of compounds showed strong antitumor activities, most of them are superior to etoposide in the inhibition against L1210 and KB cells.
摘要
通过常规方法用4-氨基-4-脱氧-4'-去甲基表鬼臼毒素进行酰化反应合成了24种4-酰氨基-4-脱氧-4'-去甲基表鬼臼毒素，并进行了体外筛选。这类化合物显示出很强的抗肿瘤活性，其中大多数在抑制L1210和KB细胞方面优于依托泊苷。
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