Escherichia coli: derived murine interleukin-1 beta with N-terminus partially N alpha-acetylated.
作者信息
Lischwe M A, Newton R C, Huang J J, Yates R A, Breth L A, Larsen B S
机构信息
Du Pont Merck Pharmaceutical Company, Glenolden Laboratory, Pennsylvania 19036.
出版信息
Protein Expr Purif. 1993 Oct;4(5):499-502. doi: 10.1006/prep.1993.1065.
PMID:8251762
Abstract
Two forms of murine recombinant interleukin-1 beta (mrIL-1 beta) from Escherichia coli were purified by ion exchange column chromatography; each exhibited equivalent biological activity in the murine thymocyte proliferation assay. It was determined by mass spectrometry of tryptic peptides that both retained the initiating methionine but one form was N alpha-acetylated at the N-terminus.
摘要
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