病毒特异性细胞毒性T淋巴细胞的原发性体外致敏
Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.
作者信息
Jung H, Pfizenmaier K, Starzinski-Powitz A, Röllinghoff M, Wagner H
出版信息
Immunology. 1978 Apr;34(4):763-9.
Abstract
CBA mouse-derived splenic lymphocytes treated with either beta-priopionlactone-inactivated or u.v. light-inactivated parainfluenza (sendai) virus stimulated in vitro unprimed syngeneic T-lymphocytes to differentiate into cytotoxic T-lymphocytes (CTL). The CTL generated were virus specific and H-2 restricted. For optimal CTL responses to be induced (i) a critical treatment of stimulator cells, (ii) an optimal ratio of responder to stimulator cells and (iii) an in vitro incubation period of 5 days was required. The in vitro system for the induction of primary virus-specific CTL responses may be useful to analyse the sensitization phase of H-2 restricted virus-specific CTL.
摘要
用β-丙内酯灭活或紫外线灭活的副流感（仙台）病毒处理的CBA小鼠来源的脾淋巴细胞，在体外刺激未致敏的同基因T淋巴细胞分化为细胞毒性T淋巴细胞（CTL）。所产生的CTL具有病毒特异性且受H-2限制。为诱导最佳的CTL反应，需要（i）对刺激细胞进行关键处理，（ii）反应细胞与刺激细胞的最佳比例，以及（iii）5天的体外孵育期。用于诱导原发性病毒特异性CTL反应的体外系统可能有助于分析H-2限制的病毒特异性CTL的致敏阶段。
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Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.病毒特异性细胞毒性T淋巴细胞的原发性体外致敏
Immunology. 1978 Apr;34(4):763-9.
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Generation of virus-specific cytotoxic T cells in vitro. I. Induction conditions of primary and secondary Sendai virus-specific cytotoxic T cells.体外病毒特异性细胞毒性T细胞的产生。I. 原发性和继发性仙台病毒特异性细胞毒性T细胞的诱导条件。
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H-2-linked murine cytotoxic T cell responses specific for sendai virus-infected cells.针对仙台病毒感染细胞的与H-2相关的小鼠细胞毒性T细胞反应。
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T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells.携带与淋巴细胞干细胞移植完全异基因胸腺移植的嵌合小鼠的T细胞介导的细胞毒性免疫反应性。
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T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted cytotoxic T lymphocyte responses across cell-impermeable membranes.体外细胞毒性T淋巴细胞反应过程中的T-T细胞相互作用。III. 抗原特异性T辅助细胞释放非特异性介质，能够帮助诱导跨细胞不可渗透膜的H-2限制性细胞毒性T淋巴细胞反应。
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Generation of virus-specific cytotoxic T cells in vitro. II. Induction requirements with functionally inactivated virus preparations.体外病毒特异性细胞毒性T细胞的产生。II. 功能失活病毒制剂的诱导要求。
Eur J Immunol. 1980 Jan;10(1):30-5. doi: 10.1002/eji.1830100107.
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Failure or success in the restoration of virus-specific cytotoxic T lymphocyte response defects by dendritic cells.树突状细胞修复病毒特异性细胞毒性T淋巴细胞反应缺陷的成败。
J Immunol. 1988 May 1;140(9):3186-93.
引用本文的文献
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Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.由单纯疱疹病毒特异性细胞毒 H-2k T 淋巴细胞介导的抗 H-2Dd 同种反应与 H-2Dk 相关。
Immunogenetics. 1980;10(4):395-404. doi: 10.1007/BF01561589.
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Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.同种反应性且受H-2限制的Lyt 23细胞毒性T淋巴细胞源自共同的前体Lyt 123前体细胞库。
J Exp Med. 1980 Nov 1;152(5):1413-8. doi: 10.1084/jem.152.5.1413.
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H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.因有意致敏而导致的H-2限制：完全异基因嵌合小鼠以及正常小鼠的T细胞在胸腺上皮细胞上未遇到的H-2决定簇的背景下对外源抗原产生反应。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7390-4. doi: 10.1073/pnas.77.12.7390.
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Complement-dependent antiviral monospecific antibody-mediated lysis of murine cells coated with Sendai virus or its envelope component.补体依赖的抗病毒单特异性抗体介导的对涂有仙台病毒或其包膜成分的鼠细胞的裂解。
Infect Immun. 1980 Feb;27(2):355-63. doi: 10.1128/iai.27.2.355-363.1980.
本文引用的文献
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T-cell cytotoxicity in the absence of viral protein synthesis in target cells.在靶细胞缺乏病毒蛋白合成的情况下T细胞的细胞毒性。
Nature. 1977 May 12;267(5607):160-3. doi: 10.1038/267160a0.
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Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses.小鼠品系和病毒株对淋巴细胞性脉络丛脑膜炎感染发病机制的影响及足垫反应研究
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Specificity and development of cytotoxic thymus-derived lymphocytes in lymphocytic choriomeningitis.淋巴细胞性脉络丛脑膜炎中细胞毒性胸腺来源淋巴细胞的特异性与发育
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T-cell-mediated immune responses induced in vitro: a probe for allograft and tumor immunity.体外诱导的T细胞介导的免疫反应：同种异体移植和肿瘤免疫的一种检测方法。
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Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.细胞介导的细胞毒性、同种异体移植排斥反应和肿瘤免疫。
Adv Immunol. 1974;18:67-132. doi: 10.1016/s0065-2776(08)60308-9.
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Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.针对H-2不相容靶细胞的病毒和三硝基苯酚半抗原特异性T细胞介导的细胞毒性。
J Exp Med. 1976 Apr 1;143(4):999-1004. doi: 10.1084/jem.143.4.999.
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Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus.由T细胞介导并受感染痘苗病毒的靶细胞的H-2抗原限制的细胞溶解作用。
Nature. 1975 Jun 12;255(5509):552-4. doi: 10.1038/255552a0.
8
Joint recognition by cytotoxic T cells of inactivated Sendai virus and products of the major histocompatibility complex.细胞毒性T细胞对灭活仙台病毒和主要组织相容性复合体产物的联合识别。
J Exp Med. 1977 Mar 1;145(3):523-39. doi: 10.1084/jem.145.3.523.
9
Virion antigens introduced exogeneously into the cell membrane render syngeneic target cells susceptible for T cell-mediated cytolysis.外源性引入细胞膜的病毒体抗原使同基因靶细胞易于受到T细胞介导的细胞溶解作用。
Z Immunitatsforsch Immunobiol. 1977 Sep;153(3):268-73.
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Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses.细胞毒性T细胞可杀死感染流感病毒的细胞，但无法区分血清学上不同的甲型病毒。
Nature. 1977 May 26;267(5609):354-6. doi: 10.1038/267354a0.
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