Hoppe D E, Bekkar B E, Nager C W
Department of Reproductive Medicine, University of California, School of Medicine, San Diego.
Obstet Gynecol. 1994 Jan;83(1):51-4.
To determine whether a single outpatient methotrexate injection successfully treats persistent ectopic pregnancy.
Nineteen consecutive patients with increasing beta-hCG titers after conservative surgery for ectopic pregnancy were treated with a single intramuscular methotrexate (50 mg/m2) injection.
All 19 patients had resolution of their beta-hCG titers without subsequent surgery. Beta-hCG levels commonly increased during the first 3 days after treatment, but subsequently declined. Two patients required hospital admission for observation and analgesia. One of these two patients had probable self-limited intra-abdominal bleeding and required a blood transfusion.
A single methotrexate injection is a safe and successful treatment for persistent ectopic pregnancy. Delayed hemorrhage may be a rare complication, and close surveillance is necessary.
确定单次门诊甲氨蝶呤注射能否成功治疗持续性异位妊娠。
19例异位妊娠保守手术后β-hCG水平持续升高的连续患者接受了单次肌内注射甲氨蝶呤（50mg/m²）治疗。
所有19例患者的β-hCG水平均恢复正常，无需后续手术。β-hCG水平通常在治疗后的前3天升高，但随后下降。2例患者需要住院观察和镇痛。这2例患者中的1例可能存在自限性腹腔内出血，需要输血。
单次甲氨蝶呤注射是治疗持续性异位妊娠的一种安全且成功的方法。延迟性出血可能是一种罕见的并发症，需要密切监测。
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