γ-氨基丁酸（GABA）转氨酶不可逆抑制剂（RMI71645）对小鼠自发活动和条件性活动的影响

[Effect of an irreversible inhibitor (RMI71645) of gamma-aminobutyric acid (GABA) transaminase on spontaneous and conditioned activities of mice].

作者信息

Misslin R, Hinschberger A, Ropartz P, Mandel P

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Oct 27;283(10):1221-4.

Abstract

The RMI, an irreversible inhibitor of GABA transaminase, inhibited, at the dose of 100 mg/kg, the activity of Mice placed in an open-field. At lower doses, RMI improved the activity in open-field and the number of conditioned avoidance reactions. Results are correlated with increase of the level of brain GABA, following administration of RMI.

摘要

RMI是一种γ-氨基丁酸转氨酶的不可逆抑制剂，以100毫克/千克的剂量抑制置于旷场中的小鼠的活动。在较低剂量下，RMI改善了旷场中的活动以及条件性回避反应的次数。这些结果与给予RMI后大脑γ-氨基丁酸水平的升高相关。