使用巨细胞旁核刺激使去甲肾上腺素能预先激活，会抑制外侧嗅束向齿状回的输入。

Lateral olfactory tract input to dentate gyrus is depressed by prior noradrenergic activation using nucleus paragigantocellularis stimulation.

作者信息

Babstock D M, Harley C W

机构信息

Psychology Department, Memorial University of Newfoundland, St John's, Canada.

出版信息

Brain Res. 1993 Nov 26;629(1):149-54. doi: 10.1016/0006-8993(93)90494-8.

DOI:10.1016/0006-8993(93)90494-8

PMID:8287269

Abstract

Nucleus paragigantocellularis stimulation potentiates the medial perforant path population spike in the dentate gyrus via beta-receptor activation. In this study, the same paragigantocellularis stimulation preceding lateral olfactory tract pulses depressed the lateral perforant path mediated synaptic potential in dentate gyrus. Depression of the lateral olfactory tract input was blocked by a beta-antagonist. These in vivo results confirm in vitro reports that norepinephrine induces potentiation of medial perforant path input and depression of lateral perforant path input to dentate gyrus.

摘要

巨细胞旁核刺激通过β受体激活增强齿状回内侧穿通通路群体峰电位。在本研究中，在外侧嗅束脉冲之前进行相同的巨细胞旁核刺激可抑制齿状回中由外侧穿通通路介导的突触电位。β拮抗剂可阻断外侧嗅束输入的抑制。这些体内实验结果证实了体外研究报告，即去甲肾上腺素可诱导齿状回内侧穿通通路输入增强和外侧穿通通路输入抑制。