[X射线造影剂对人和大鼠体内及体外血液中血栓素和前列环素含量的影响]
[The effect of x-ray contrast media on the amount of thromboxane and prostacyclin in the blood of man and rats in vivo and in vitro].
作者信息
Napolov Iu K, Shimanovskiĭ N L, Bolotova E N, Borsukova N M, Sergeev P V
出版信息
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):41-3.
PMID:8312809
Abstract
The in vivo and in vitro effects of radioopaque agents such as bilignost, iodamide, and triombrast on blood thromboxane B2 (TxB2) and prostacyclin levels were studied in man and rats. These radioopaque agents were demonstrated to increase prostacyclin levels and to decrease TxB2 in the plasma by 40%, as evidenced by urography when given in vivo (1-2 g/kg) and in vitro (2.5.10(-2) M and 2.5.10(-3) M).
摘要
研究了不透射线造影剂如必利胆影、碘酰胺和碘番酸对人和大鼠血液中血栓素B2（TxB2）和前列环素水平的体内及体外效应。当体内（1 - 2 g/kg）和体外给予这些不透射线造影剂（2.5×10⁻² M和2.5×10⁻³ M）时，经尿路造影证实，这些造影剂可使前列环素水平升高，并使血浆中TxB2降低40%。
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