Balon R, Yeragani V K, Pohl R, Ramesh C
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich.
J Clin Psychiatry. 1993 Jun;54(6):209-12.
The reported incidence of sexual dysfunction associated with antidepressant medication varies from 1.9% to 92%. The majority of studies reporting incidences were not systematically conducted.
We interviewed 60 patients (22 men and 38 women, with anxiety and mood disorders) who were being treated with various antidepressants. We used a questionnaire focused on sexual side effects and other side effects.
The incidence of sexual dysfunction during antidepressant use in our study is 43.3%. The sexual dysfunction was not limited to any particular diagnostic group nor to any particular antidepressant. There was no significant correlation between sexual dysfunction and anticholinergic side effects. The incidence of painful orgasm with antidepressants was 18% among males in our study.
The relatively high incidence of sexual dysfunction associated with antidepressant treatment in this systematic study emphasizes the importance of a detailed inquiry about sexual side effects as this interferes with treatment compliance.
据报道，与抗抑郁药物相关的性功能障碍发生率在1.9%至92%之间。大多数报告发生率的研究并非系统开展。
我们采访了60名正在接受各种抗抑郁药物治疗的患者（22名男性和38名女性，患有焦虑和情绪障碍）。我们使用了一份聚焦于性副作用和其他副作用的问卷。
在我们的研究中，抗抑郁药物使用期间性功能障碍的发生率为43.3%。性功能障碍并不局限于任何特定的诊断组，也不局限于任何特定的抗抑郁药物。性功能障碍与抗胆碱能副作用之间无显著相关性。在我们的研究中，男性使用抗抑郁药物后出现性高潮疼痛的发生率为18%。
在这项系统性研究中，与抗抑郁治疗相关的性功能障碍发生率相对较高，这凸显了详细询问性副作用的重要性，因为这会影响治疗依从性。
