职业暴露与甲状腺癌：一项病例对照研究的结果
Occupational exposures and thyroid cancer: results of a case-control study.
作者信息
Hallquist A, Hardell L, Degerman A, Boquist L
机构信息
Department of Oncology, University Hospital, Umeå, Sweden.
出版信息
Eur J Cancer Prev. 1993 Jul;2(4):345-9. doi: 10.1097/00008469-199307000-00009.
A case-control study on thyroid cancer concerning 180 cases and 360 controls aged 20-70 years at diagnosis was performed. Both females and males were included. Of the cases, 63% had had papillary thyroid cancer. Work with diagnostic X-ray investigations constituted a risk factor for thyroid cancer of the papillary type yielding an odds ratio (OR) of 2.9 with 95% confidence interval (CI) = 1.1-8.3. For women only OR was 3.3 (CI = 1.2-9.8). The results also indicated that work as a lineman, which entails exposure to electromagnetic fields and chemicals, increased the risk. Exposure to impregnating agents gave an increased OR = 2.8 with CI = 1.0-8.6. For men only OR was 3.8 with CI = 1.1-16. Women who were previously smokers and female current smokers had significantly decreased risks with OR = 0.5 (CI = 0.2-0.96) and OR = 0.6 (CI = 0.3-0.96), respectively.
开展了一项关于甲状腺癌的病例对照研究，涉及180例病例和360名对照，诊断时年龄在20至70岁之间。纳入了男性和女性。在这些病例中，63%患有乳头状甲状腺癌。从事诊断性X线检查工作是乳头状甲状腺癌的一个危险因素，优势比（OR）为2.9，95%置信区间（CI）=1.1 - 8.3。仅对于女性，OR为3.3（CI = 1.2 - 9.8）。结果还表明，从事线路工人工作，这会接触到电磁场和化学物质，会增加风险。接触浸渍剂使OR升高至2.8，CI = 1.0 - 8.6。仅对于男性，OR为3.8，CI = 1.1 - 16。既往吸烟者和当前吸烟的女性风险显著降低，OR分别为0.5（CI = 0.2 - 0.96）和0.6（CI = 0.3 - 0.96）。
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