丁硫氨酸亚砜胺增强顺铂对人胃癌细胞的体内外抗肿瘤活性。
Enhancement of antitumor activity of cisplatin on human gastric cancer cells in vitro and in vivo by buthionine sulfoximine.
作者信息
Saikawa Y, Kubota T, Kuo T H, Furukawa T, Tanino H, Watanabe M, Ishibiki K, Kitajima M
机构信息
Department of Surgery, School of Medicine, Keio University, Tokyo.
出版信息
Jpn J Cancer Res. 1993 Jul;84(7):787-93. doi: 10.1111/j.1349-7006.1993.tb02045.x.
An attempt was made to evaluate the enhancement of the antitumor activity of cisplatin (DDP) by buthionine sulfoximine (BSO) in vitro and in vivo. In the in vitro study, pre-treatment with BSO (5, 10 and 25 mM) increased the antitumor activity of DDP against the gastric cancer cell lines MKN-28 and MKN-45, whereas BSO alone exhibited only slight antitumor activity (inhibition rate, 20-30%). In the in vivo study, the antitumor effects of DDP against human gastric cancer xenografts St-15 and SC-1-NU in BALB/c nu/nu mice were enhanced pretreatment with BSO, which was administered intraperitoneally at a dose of 500 mg/kg according to a schedule of qd x 3. BSO alone showed no antitumor effects against these tumors in nude mice. The side effects (assessed in terms of death rate and body weight loss) associated with the maximum tolerated dose of DDP (9 mg/kg) were not increased by BSO pretreatment. As BSO increased the antitumor activity of DDP without a corresponding increment of its toxicity, BSO appears to be a promising agent for further study.
尝试在体外和体内评估丁硫氨酸亚砜胺（BSO）对顺铂（DDP）抗肿瘤活性的增强作用。在体外研究中，用BSO（5、10和25 mM）预处理可增强DDP对胃癌细胞系MKN - 28和MKN - 45的抗肿瘤活性，而单独使用BSO仅表现出轻微的抗肿瘤活性（抑制率为20 - 30%）。在体内研究中，在BALB/c nu/nu小鼠中，对人胃癌异种移植瘤St - 15和SC - 1 - NU，DDP的抗肿瘤作用通过BSO预处理得到增强，BSO按照每日一次×3的给药方案以500 mg/kg的剂量腹腔注射。单独使用BSO对裸鼠中的这些肿瘤没有抗肿瘤作用。与DDP最大耐受剂量（9 mg/kg）相关的副作用（根据死亡率和体重减轻评估）并未因BSO预处理而增加。由于BSO增加了DDP的抗肿瘤活性而其毒性没有相应增加，BSO似乎是一种有前景的进一步研究药物。
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