Hummelt H, Jennewein H M, Treichel R, Waldeck F
Digestion. 1977 Feb;15(2):151-5. doi: 10.1159/000197996.
The aim of the present study was to investigate the mode of the inhibitory effect of somatostatin on gastric acid secretion. This was done in Heidenhain-pouch dogs studying the effect of somatostatin on cumulative dose response curves of pentagastrin, carbachol and histamine. Somatostatin inhibited gastric secretion after all three stimuli, with decreasing potency against carbachol, pentagastrin and histamine. The pentagastrin-stimulated acid secretion was inhibited in a noncompetitive way; in contrary to this the carbachol and also the histamine-stimulated secretion was inhibited in a competitive way.
本研究的目的是探讨生长抑素对胃酸分泌的抑制作用模式。这是在海登海因小胃犬身上进行的，研究生长抑素对五肽胃泌素、卡巴胆碱和组胺累积剂量反应曲线的影响。生长抑素在所有三种刺激后均抑制胃酸分泌，对卡巴胆碱、五肽胃泌素和组胺的抑制效力逐渐降低。五肽胃泌素刺激的胃酸分泌以非竞争性方式被抑制；与此相反，卡巴胆碱和组胺刺激的分泌以竞争性方式被抑制。
