血栓素A2受体拮抗剂对豚鼠9α,11β-前列腺素F2诱导的支气管高反应性的抑制作用

Inhibition of 9 alpha,11 beta-prostaglandin F2-induced bronchial hyperresponsiveness by thromboxane A2 receptor antagonists in guinea pigs.

作者信息

Kurosawa M, Yodonawa S, Tsukagoshi H

机构信息

First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.

出版信息

Eur J Pharmacol. 1993 Jul 20;238(2-3):335-41. doi: 10.1016/0014-2999(93)90865-f.

DOI:10.1016/0014-2999(93)90865-f

PMID:8405102

Abstract

We studied the effect of intravenous administration of 9 alpha,11 beta-prostaglandin F2 on bronchial responsiveness to histamine and airway wall thickening in guinea pigs. The infusion of 9 alpha,11 beta-prostaglandin F2 induced an increase of the relative thickness of the airway wall in peripheral bronchi demonstrable by histological examination. Analysis of airway function showed that the infusion of 9 alpha,11 beta-prostaglandin F2 induced airway hyperresponsiveness to histamine with airway wall thickening. The thromboxane A2 receptor antagonists, ONO-NT-126 (5(Z)-6-[(1R,2R,3R,4S)-3-(n-4-bromobenzenesulfonyl-aminomethyl) bicyclo[2.2.1]heptane-2-yl]hex-5-enoic acid) and ONO-8809 (n-decyl(Z)-6-[(1S,2S,3R,4R)-3-(4-bromobenzenesulfonylaminomethyl) bicyclo[2.2.1]hept-2-yl]-5-hexenoate), inhibited these effects of 9 alpha,11 beta-prostaglandin F2 in a dose-dependent manner.

摘要

我们研究了静脉注射9α,11β-前列腺素F2对豚鼠支气管对组胺的反应性及气道壁增厚的影响。通过组织学检查可证实，输注9α,11β-前列腺素F2可导致外周支气管气道壁相对厚度增加。气道功能分析表明，输注9α,11β-前列腺素F2可诱导气道对组胺的高反应性并伴有气道壁增厚。血栓素A2受体拮抗剂ONO-NT-126（5(Z)-6-[(1R,2R,3R,4S)-3-(n-4-溴苯磺酰氨基甲基)双环[2.2.1]庚烷-2-基]己-5-烯酸）和ONO-8809（正癸基(Z)-6-[(1S,2S,3R,4R)-3-(4-溴苯磺酰氨基甲基)双环[2.2.1]庚-2-基]-5-己烯酸）可剂量依赖性地抑制9α,11β-前列腺素F2的这些作用。