Sinke R J, de Leeuw B, Janssen H A, Weghuis D O, Suijkerbuijk R F, Meloni A M, Gilgenkrantz S, Berger W, Ropers H H, Sandberg A A
Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
Hum Genet. 1993 Oct 1;92(3):305-8. doi: 10.1007/BF00244478.
A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.
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