新西兰波利尼西亚人的HLA - DR4亚型。健康人群中Dw13占主导，Dw15与类风湿性关节炎相关。

HLA-DR4 subtypes in New Zealand Polynesians. Predominance of Dw13 in the healthy population and association of Dw15 with rheumatoid arthritis.

作者信息

Tan P L, Farmiloe S, Roberts M, Geursen A, Skinner M A

机构信息

Department of Molecular Medicine, University of Auckland School of Medicine, New Zealand.

出版信息

Arthritis Rheum. 1993 Jan;36(1):15-9. doi: 10.1002/art.1780360104.

DOI:10.1002/art.1780360104

PMID:8424833

Abstract

OBJECTIVE

To analyze HLA-DR4 alleles in New Zealand Polynesians with rheumatoid arthritis (RA).

METHODS

Thirty Polynesians and 30 Caucasians with RA, as well as 65 Polynesian and 60 Caucasian healthy blood donors, were DR4 subtyped using the polymerase chain reaction and sequence-specific oligonucleotide probes.

RESULTS

The frequency of DR4 (DRB104) was increased in both Polynesian (P < 0.001) and Caucasian (P < 0.005) RA patients compared with race-matched controls. Dw4 (DRB10401) was detected in 15 of 30 Caucasian patients but only 2 of 30 Polynesian patients (P < 0.001). In Polynesians, RA was associated with Dw15 (DRB10405), which was present in 11 of 30 patients and 3 of 65 controls (P < 0.001). Dw13 (DRB10403) was the most frequent DR4 allele in healthy Polynesians, but was not significantly associated with RA.

CONCLUSION

The predominance of the Dw13 subtype in Polynesians may explain in part the low prevalence of RA in this population. The association of Dw15 with RA in Polynesians supports the hypothesis that the third hypervariable region of DR beta determines susceptibility to RA.

摘要

目的

分析新西兰患类风湿性关节炎（RA）的波利尼西亚人的HLA - DR4等位基因。

方法

采用聚合酶链反应和序列特异性寡核苷酸探针，对30名患RA的波利尼西亚人、30名患RA的高加索人以及65名波利尼西亚健康献血者和60名高加索健康献血者进行DR4亚型分型。

结果

与种族匹配的对照组相比，患RA的波利尼西亚人（P < 0.001）和高加索人（P < 0.005）中DR4（DRB104）的频率均有所增加。在30名高加索患者中有15名检测到Dw4（DRB10401），而在30名波利尼西亚患者中仅2名检测到（P < 0.001）。在波利尼西亚人中，RA与Dw15（DRB10405）相关，30名患者中有11名存在该基因，65名对照中有3名存在（P < 0.001）。Dw13（DRB10403）是健康波利尼西亚人中最常见的DR4等位基因，但与RA无显著相关性。