一种进化上古老的人类α卫星DNA的特征分析。

Characterization of an evolutionarily old human alphoid DNA.

作者信息

Carnahan S L, Palamidis-Bourtsos E, Musich P R, Doering J L

机构信息

Department of Biology, Loyola University of Chicago, IL 60626.

出版信息

Gene. 1993 Jan 30;123(2):219-25. doi: 10.1016/0378-1119(93)90127-o.

DOI:10.1016/0378-1119(93)90127-o

PMID:8428661

Abstract

A recently isolated human alphoid DNA (in plasmid pHH550) has been sequenced and found to have an exceptionally high degree of similarity to the human alphoid consensus sequence, while its component monomers are unusually heterogeneous in sequence. In contrast to other alphoid DNAs, this DNA is found in all primates tested. Thus this may be an evolutionarily old sequence similar to the one from which other human alphoid DNAs diverged. The pHH550 sequences are found on a number of human chromosomes, including 21 and 22. On chromosome 21 most members of this new sequence group are located distal to other alphoid DNAs.

摘要

最近分离出的一种人类α卫星DNA（存在于质粒pHH550中）已完成测序，发现它与人类α卫星共有序列具有极高的相似性，而其组成单体在序列上异常不均一。与其他α卫星DNA不同的是，在所有测试的灵长类动物中都发现了这种DNA。因此，这可能是一个进化上古老的序列，类似于其他人类α卫星DNA从中分化出来的序列。pHH550序列存在于多条人类染色体上，包括21号和22号染色体。在21号染色体上，这个新序列组的大多数成员位于其他α卫星DNA的远端。