Beneficial effects of the combined use of prenatal corticosteroids and postnatal surfactant on preterm infants.
作者信息
Jobe A H, Mitchell B R, Gunkel J H
机构信息
Division of Perinatal Research, Harbor-University of California, Los Angeles Medical Center, Torrance 90509.
出版信息
Am J Obstet Gynecol. 1993 Feb;168(2):508-13. doi: 10.1016/0002-9378(93)90483-y.
OBJECTIVE
Our objective was to test the hypothesis that prenatal maternal corticosteroids would improve the subsequent response of infants to surfactant treatments.
STUDY DESIGN
We used the data bases of two recently published large multicenter trials of multidose surfactant treatments to retrospectively evaluate the possible interactions between maternal corticosteroids and randomized surfactant treatments on short-term ventilatory effects, complications of respiratory distress syndrome and prematurity, and 28-day death rates.
RESULTS
The combined use of corticosteroids and surfactant significantly decreased overall death and death caused by respiratory distress syndrome relative to either treatment alone. Ventilatory variables at 72 hours were improved in those infants receiving both treatments, and other major complications of prematurity also tended to have decreased incidences.
CONCLUSION
The combined use of prenatal corticosteroids, when indicated, and postnatal surfactant improves neonatal outcome.
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