Kajita M, Niwa T, Takeda N, Yoshizumi H, Tatematsu A, Watanabe K, Nagatsu T
Department of Pediatrics, Nagoya University School of Medicine, Japan.
J Chromatogr. 1993 Mar 5;613(1):1-8. doi: 10.1016/0378-4347(93)80190-f.
N-Methyldopamine (epinine) has been identified for the first time in parkinsonian and normal human brains by gas chromatography-mass spectrometry. N-Methylsalsolinol and N-methylnorsalsolinol, which are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces parkinsonism in humans, may be synthesized from N-methyldopamine by the Pictet-Spengler condensation reaction as an alternative metabolic pathway.
通过气相色谱 - 质谱法首次在帕金森病患者和正常人脑中鉴定出N - 甲基多巴胺（去甲肾上腺素）。N - 甲基去甲猪毛菜碱和N - 甲基去甲去甲猪毛菜碱是1 - 甲基 - 4 - 苯基 - 1,2,3,6 - 四氢吡啶的类似物，后者可在人体内产生帕金森病，它们可能是由N - 甲基多巴胺通过Pictet - Spengler缩合反应合成的，作为一种替代代谢途径。
