Common expression of parathyroid hormone-related protein and no correlation of calcium level in renal cell carcinomas.

作者信息

Gotoh A, Kitazawa S, Mizuno Y, Takenaka A, Arakawa S, Matsumoto O, Kitazawa R, Fujimori T, Maeda S, Kamidono S

机构信息

Department of Urology, Kobe University School of Medicine, Japan.

出版信息

Cancer. 1993 May 1;71(9):2803-6. doi: 10.1002/1097-0142(19930501)71:9<2803::aid-cncr2820710919>3.0.co;2-s.

BACKGROUND

Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM).

METHODS

Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal human kidney tissues and tissues from 42 human renal cell carcinomas obtained at operation or autopsy.

RESULTS

In normal renal tissues, the distal tubules and collecting ducts showed positive immunostaining. PTHrP was detected in 40 of 42 renal cell carcinoma tissues (95%). Histopathologically, the granular cell subtypes of renal cell carcinomas tended to be more strongly positive than the clear cell subtypes. There was no significant correlation between the level of immunostaining and each patient's serum calcium level.

CONCLUSION

PTHrP was commonly observed in renal cell carcinomas, and no significant correlation was seen between the intensity of PTHrP staining and the serum calcium level.