在鼠类利什曼病中，TH1和TH2 T细胞亚群被巨噬细胞和B细胞以不同方式激活。
TH1 and TH2 T-cell subsets are differentially activated by macrophages and B cells in murine leishmaniasis.
作者信息
Rossi-Bergmann B, Müller I, Godinho E B
机构信息
Institute of Biophysics, Federal University of Rio de Janeiro, Brazil.
出版信息
Infect Immun. 1993 May;61(5):2266-9. doi: 10.1128/iai.61.5.2266-2269.1993.
Abstract
The role of antigen-presenting cells in the differential expansion of TH1 and TH2 T cells in murine leishmaniasis was investigated. In general, macrophages preferentially induced gamma interferon and interleukin-2 secretion by syngeneic Leishmania-specific T cells, whereas B cells were more efficient in activating interleukin 4 production. B cells from susceptible BALB/c mice were better in inducing TH2 responses than B cells from resistant C57BL/6 mice, whereas macrophages from C57BL/6 mice were superior to BALB/c macrophages in inducing TH1 responses.
摘要
研究了抗原呈递细胞在小鼠利什曼病中TH1和TH2 T细胞差异扩增中的作用。一般来说，巨噬细胞优先诱导同基因利什曼原虫特异性T细胞分泌γ干扰素和白细胞介素-2，而B细胞在激活白细胞介素4产生方面更有效。来自易感BALB/c小鼠的B细胞在诱导TH2反应方面比来自抗性C57BL/6小鼠的B细胞更好，而来自C57BL/6小鼠的巨噬细胞在诱导TH1反应方面优于BALB/c巨噬细胞。
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本文引用的文献
1
Susceptibility of inbred mice to Leishmania tropica infection: correlation of susceptibility with in vitro defective macrophage microbicidal activities.
Cell Immunol. 1983 Apr 15;77(2):298-307. doi: 10.1016/0008-8749(83)90030-8.
2
3
Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones.
J Immunol. 1984 Jun;132(6):2924-31.
4
Separation of mouse spleen cells by passage through columns of sephadex G-10.
J Immunol Methods. 1974 Aug;5(3):239-47. doi: 10.1016/0022-1759(74)90108-2.
5
A rapid method for the isolation of functional thymus-derived murine lymphocytes.
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
6
7
8
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.
J Exp Med. 1987 Nov 1;166(5):1229-44. doi: 10.1084/jem.166.5.1229.
9
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.
J Exp Med. 1988 Nov 1;168(5):1675-84. doi: 10.1084/jem.168.5.1675.
10
Functional heterogeneity of CD4+ T cells in leishmaniasis.
Immunol Today. 1989 Feb;10(2):40-5. doi: 10.1016/0167-5699(89)90302-2.
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