Illes P, Nörenberg W
Department of Pharmacology, University of Freiburg, Federal Republic of Germany.
Trends Pharmacol Sci. 1993 Feb;14(2):50-4. doi: 10.1016/0165-6147(93)90030-n.
ATP stores and supplies energy in neurons, but it also acts as a transmitter molecule. ATP activates a class of membrane receptors termed P2 purinoceptors. Based on the potencies of structural analogues of ATP, P2 purinoceptors in non-neuronal tissues were classified by classic pharmacological methods into two subtypes, P2x and P2y. Peter Illes and Wolfgang Nörenberg report that electrophysiological investigations indicate the presence of P2y-like purinoceptors on neurons. They describe two alternative ionic transduction mechanisms that may be activated by this receptor family.
三磷酸腺苷（ATP）在神经元中储存并供应能量，但它也作为一种递质分子发挥作用。ATP激活一类称为P2嘌呤受体的膜受体。根据ATP结构类似物的效能，非神经组织中的P2嘌呤受体通过经典药理学方法被分为两个亚型，P2x和P2y。彼得·伊莱斯和沃尔夫冈·诺伦贝格报告称，电生理研究表明神经元上存在P2y样嘌呤受体。他们描述了可能被该受体家族激活的两种替代性离子转导机制。
