氧氟沙星在前列腺液、精液及精浆中的渗透情况。 （注：原文中多了一个of，正确表述应该是Penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid. ）
Penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid.
作者信息
Naber K G, Kinzig M, Sörgel F, Weigel D
机构信息
Urologische Klinik, Elisabeth Krankenhaus, Straubing, Germany.
出版信息
Infection. 1993 Mar-Apr;21(2):98-100. doi: 10.1007/BF01710740.
The penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid was measured by a high-pressure liquid chromatography (HPLC) method after intravenous infusion (60 min) of 400 mg in six healthy male volunteers. The median concentration of ofloxacin in prostatic fluid was about one-third and that in ejaculate and seminal fluid about twice that in corresponding plasma. The results of the study indicate good penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid. Ofloxacin should thus be of value for the treatment of chronic bacterial prostatitis and vesiculitis.
在6名健康男性志愿者静脉输注400毫克（60分钟）后，采用高压液相色谱（HPLC）法测定了氧氟沙星在前列腺液、精液和精浆中的渗透情况。氧氟沙星在前列腺液中的中位浓度约为相应血浆浓度的三分之一，在精液和精浆中的浓度约为相应血浆浓度的两倍。研究结果表明氧氟沙星在前列腺液、精液和精浆中有良好的渗透性。因此，氧氟沙星对治疗慢性细菌性前列腺炎和精囊炎应具有价值。
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