[用氯化奥昔布宁进行神经源性尿失禁的局部治疗]
[Topical treatment with oxybutynin chloride in neurogenic incontinence].
作者信息
López Pereira P, Martínez M J, Muguerza R, Jaureguizar E
机构信息
Departamento de Cirugía Pediátrica, Unidad de Urología, Hospital Infantil La Paz, Madrid.
出版信息
Cir Pediatr. 1993 Jan;6(1):29-31.
Intravesical oxybutynin chloride was administered to 12 children with neurogenic bladder and incontinence who had unacceptable side effects. Urodynamic studies showed hyperreflexia was eliminated or improvement in 100% of them and low compliance was improved (88%), with a mean increase in bladder volume to 123% and a mean decrease of filling pressure to 24 cm H2O. Six patients became completely dry (50%), 4 continent period was increased and 2 did not improve. No systemic effects were observed.
对12名患有神经源性膀胱和尿失禁且出现难以接受的副作用的儿童给予膀胱内注射氯化奥昔布宁。尿动力学研究表明，100%的患儿反射亢进消失或有所改善，低顺应性得到改善（88%），膀胱容量平均增加至123%，充盈压平均降低至24 cm H₂O。6名患者完全不再尿床（50%），4名患者的控尿期延长，2名患者未见改善。未观察到全身影响。
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