[甲苯咪唑对细粒棘球绦虫囊壁中葡萄糖、糖原、乳酸和乳酸脱氢酶的影响]

[Effects of mebendazole on glucose, glycogen, lactic acid, and lactate dehydrogenase in Echinococcus granulosus cyst wall].

作者信息

Xiao S H, Feng J J, Guo H F, Jiao P Y, Yao M Y, Chai J J

机构信息

Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai, China.

出版信息

Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):42-5.

PMID:8503286

Abstract

The glucose, glycogen, and lactic acid contents in Echinococcus granulosus cyst wall were 3570 +/- 623, 1276 +/- 126, and 267 +/- 29 micrograms.g-1, respectively. The lactate dehydrogenase (LDH) activity in the cyst wall was 4307 +/- 297 U/(min.mg protein). When infected mice were treated ig with mebendazole (Meb) 25 or 50 mg.kg-1.d-1 for 7-14 d, the glucose and glycogen contents in the cyst wall decreased markedly. No apparent changes in lactic acid and LDH activity were seen. The results suggested that Meb had no effect on glycolysis of the cyst wall, but it exhibited an inhibitory effect on the transport of exogenous glucose from the host to the cyst wall, which might further promote the decomposition of endogenous glycogen for energy supply and resulted in a decrease of endogenous glycogen content in the cyst wall.

摘要

细粒棘球绦虫囊壁中的葡萄糖、糖原和乳酸含量分别为3570±623、1276±126和267±29微克·克⁻¹。囊壁中的乳酸脱氢酶（LDH）活性为4307±297单位/（分钟·毫克蛋白质）。当感染小鼠经口给予甲苯达唑（Meb）25或50毫克·千克⁻¹·天⁻¹，持续7 - 14天时，囊壁中的葡萄糖和糖原含量显著降低。乳酸和LDH活性未见明显变化。结果表明，Meb对囊壁的糖酵解无影响，但对宿主中外源葡萄糖向囊壁的转运具有抑制作用，这可能进一步促进内源性糖原分解以提供能量，导致囊壁内源性糖原含量降低。