Kamo I, Kunishita T, Kikuchi A, Nonaka I, Komiyama A
National Institute of Neuroscience, NCNP, Tokyo, Japan.
Immunology. 1993 May;79(1):103-6.
Thymic myoid cells produced macrophage lineage cell stimulatory factors. Activities were separated into two factors on DEAE-Sepharose CL-6B chromatography: one eluted at lower concentrations of NaCl and the other at higher concentrations of NaCl. The latter fraction was purified to homogeneity with an apparent molecular weight of 100,000. This factor stimulated the growth of macrophage-lineage cells from the bone marrow, but not that of granulocytes, megakaryocytes or erythroblasts. The 100,000 MW factor was able to induce Ia antigens on proliferating bone marrow cells. These results suggest that myoid cell-derived 100,000 MW factor plays significant roles in the generation of Ia-positive macrophage lineage cells which are important for T-cell development in the thymus.
胸腺肌样细胞产生巨噬细胞系细胞刺激因子。通过DEAE-琼脂糖CL-6B层析将活性分离为两种因子：一种在较低浓度的NaCl中洗脱，另一种在较高浓度的NaCl中洗脱。后一种组分被纯化至同质，表观分子量为100,000。该因子刺激来自骨髓的巨噬细胞系细胞的生长，但不刺激粒细胞、巨核细胞或成红细胞的生长。100,000分子量的因子能够在增殖的骨髓细胞上诱导Ia抗原。这些结果表明，肌样细胞衍生的100,000分子量因子在Ia阳性巨噬细胞系细胞的产生中起重要作用，而Ia阳性巨噬细胞系细胞对胸腺中T细胞的发育很重要。
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