[癌基因及其发现]
[Oncogenes and their discovery].
作者信息
Chabert-Gisselbrecht S
机构信息
Institut Cochin de génétique moléculaire, Hôpital Cochin, Paris.
出版信息
Rev Prat. 1995 Oct 1;45(15):1873-80.
Oncogenes have been discovered through the study of oncogenic retroviruses. Viral oncogenes present in the viral genome are the genes responsible for the transforming properties of these viruses. Viral oncogenes are altered forms of cellular genes, designated as proto-oncogenes, that have been transduced into the genome of transforming retroviruses. Deregulated expression or structural alteration of cellular proto-oncogenes by amplification, mutation or translocation has been implicated in the occurrence of human cancers.
通过对致癌逆转录病毒的研究发现了癌基因。病毒基因组中存在的病毒癌基因是这些病毒具有转化特性的原因。病毒癌基因是细胞基因的改变形式，被称为原癌基因，已被转导到转化逆转录病毒的基因组中。细胞原癌基因通过扩增、突变或易位导致的表达失调或结构改变与人类癌症的发生有关。
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