急性髓系白血病中仅作为细胞遗传学异常的5号染色体三体新病例。

A new case of trisomy 5 as sole cytogenetic anomaly in acute myeloid leukemia.

作者信息

Ríos R, Solé F, Montes C, Vicente A, Pérez M M, Valle M, Gascón F

机构信息

Unit of Hematology, Hospital Valle de los Pedroches, Córdoba, Spain.

出版信息

Cancer Genet Cytogenet. 1995 Oct 15;84(2):120-2. doi: 10.1016/0165-4608(95)00098-4.

DOI:10.1016/0165-4608(95)00098-4

PMID:8536225

Abstract

We present a case of acute myeloid leukemia (AML-M2) with trisomy 5 (+5) as the sole cytogenetic abnormality in a woman previously diagnosed with schizophrenia. To date, only two cases of AML (other than M2) with +5 as the only change have been reported. Moreover, an association between schizophrenia and partial trisomy of chromosome 5p has been described recently. To our knowledge, this is the first report of AML (subtype-M2) with +5. Noteworthy is the association with schizophrenia.

摘要

我们报告一例急性髓系白血病（AML-M2），该患者为一名先前被诊断患有精神分裂症的女性，其唯一的细胞遗传学异常为5号染色体三体（+5）。迄今为止，仅报道过两例以+5作为唯一变化的急性髓系白血病（M2型除外）。此外，最近已有关于精神分裂症与5号染色体短臂部分三体之间关联的描述。据我们所知，这是首例关于伴有+5的急性髓系白血病（M2亚型）的报告。值得注意的是其与精神分裂症的关联。