在狒狒模型中，使用碘-123-15-（碘苯基）十五烷酸（IPPA）和碘-123-15-（对碘苯基）-3-R，S-甲基十五烷酸（BMIPP）进行平面心肌显像，并利用时间-活性曲线评估代谢。

Planar myocardial imaging in the baboon model with iodine-123-15-(iodophenyl)pentadecanoic acid (IPPA) and iodine-123-15-(P-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), using time-activity curves for evaluation of metabolism.

作者信息

Dormehl I C, Hugo N, Rossouw D, White A, Feinendegen L E

机构信息

Institute for Life Sciences, University of Pretoria, South Africa.

出版信息

Nucl Med Biol. 1995 Oct;22(7):837-47. doi: 10.1016/0969-8051(95)00015-p.

DOI:10.1016/0969-8051(95)00015-p

PMID:8547881

Abstract

The purpose of this study was to compare by planar myocardial scintigraphy the kinetics of iodine-123-15-(iodophenyl)pentadecanoic acid (123I-pPPA and 123I-oPPA), and of iodine-123-(p-iodophenyl)-3-R,S-methyl-pentadecanoic acid (BMIPP), firstly in normal baboons, and subsequently after blocking fatty acid oxidation by a carnitine palmitoyl transferase I(CPT1) inhibitor. The induced changes in myocardial metabolism were reflected in the dynamic behaviour of the three tracers. pPPA and oPPA to a large extent, provided information on beta-oxidation changes in the myocardium: beta-oxidation participation changed from 47% and 50%, respectively to 17% and 23% after inhibition. BMIPP provided better images and reflected largely on changed tracer incorporation into the neutral lipid pools. The beta-oxidation contributed only about 10% towards the metabolic pathway of BMIPP. The information obtained in this study could help determine the tracer of choice for SPECT, whereby myocardial viability could optimally be revealed.

摘要

本研究的目的是通过平面心肌闪烁显像术，首先在正常狒狒中，然后在使用肉碱棕榈酰转移酶I（CPT1）抑制剂阻断脂肪酸氧化后，比较碘-123-15-（碘苯基）十五烷酸（123I-pPPA和123I-oPPA）以及碘-123-（对碘苯基）-3-R，S-甲基十五烷酸（BMIPP）的动力学。心肌代谢的诱导变化反映在这三种示踪剂的动态行为中。pPPA和oPPA在很大程度上提供了有关心肌β氧化变化的信息：抑制后，β氧化参与率分别从47%和50%变为17%和23%。BMIPP提供了更好的图像，并在很大程度上反映了示踪剂掺入中性脂质池的变化。β氧化仅占BMIPP代谢途径的约10%。本研究获得的信息有助于确定单光子发射计算机断层显像（SPECT）的首选示踪剂，从而能够最佳地揭示心肌活力。