输血导致抗PLA1抗体被动转移引起的新生儿血小板减少症。

Neonatal thrombocytopenia caused by passive transfer of anti-PLA1 antibody by blood transfusion.

作者信息

Marzich C, Strohm P L, Ayas M, Cochran R K

机构信息

Department of Pathology, Western Reserve Care System, Youngstown, Ohio 44501, USA.

出版信息

J Pediatr. 1996 Jan;128(1):137-9. doi: 10.1016/s0022-3476(96)70444-4.

DOI:10.1016/s0022-3476(96)70444-4

PMID:8551405

Abstract

A premature male infant with hyaline membrane disease received a 34 ml transfusion of packed erythrocytes from a CPDA1 blood unit on day 2 with no adverse consequences. On day 34 he was given a transfusion, and the platelet count decreased. Intravenous immune globulin therapy was initiated and the platelet count steadily increased. Human leukocyte (HLA) antigen and platelet antibody testing showed that the thrombocytopenia was due to passive transfer of platelet-specific antibody from the blood donor.

摘要

一名患有透明膜病的早产男婴在出生第2天接受了来自一个CPDA1血液单位的34毫升浓缩红细胞输血，未出现不良后果。在第34天，他接受了一次输血，随后血小板计数下降。开始进行静脉注射免疫球蛋白治疗，血小板计数稳步上升。人类白细胞（HLA）抗原和血小板抗体检测显示，血小板减少是由于献血者的血小板特异性抗体被动转移所致。