注入伏隔核的7-羟基-DPAT可减少运动和蔗糖摄取：D3自身受体介导的效应？

7-OH-DPAT injected into the accumbens reduces locomotion and sucrose ingestion: D3 autoreceptor-mediated effects?

作者信息

Gilbert D B, Cooper S J

机构信息

Division of Psychology, School of Health and Human Sciences, University of Hertfordshire, Hatfield, United Kingdom.

出版信息

Pharmacol Biochem Behav. 1995 Oct;52(2):275-80. doi: 10.1016/0091-3057(95)00113-b.

DOI:10.1016/0091-3057(95)00113-b

PMID:8577791

Abstract

7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) injected bilaterally in the nucleus accumbens (NAC) resulted in profound, noncatatonic, dose-dependent (0.3-3 mg total dose) hypolocomotion but without inducing yawning. It also decreased intake of a highly preferred 3% sucrose solution (1 microgram total dose). Systemic injection of 7-OH-DPAT (0.1-3.0 mg/kg, i.p.) similarly induced hypolocomotion while failing to induce yawning. In none of these studies did rats show any signs of hyperlocomotion or any stereotyped responses normally associated with D2 or mixed D1/D2 receptor stimulation. These data suggest that hypolocomotion elicited by 7-OH-DPAT in the NAC may be mediated at the D3 receptor as distinct from the D2 dopamine receptor. We discuss the possibility that the behavioural effects we observed are mediated at D3 autoreceptors.

摘要

双侧伏隔核（NAC）注射7-羟基-N,N-二正丙基-2-氨基四氢萘（7-OH-DPAT）会导致深度、非紧张性、剂量依赖性（总剂量0.3 - 3毫克）的运动减少，但不会引发打哈欠。它还会减少对高度偏好的3%蔗糖溶液的摄取（总剂量1微克）。全身注射7-OH-DPAT（0.1 - 3.0毫克/千克，腹腔注射）同样会引起运动减少，同时不会引发打哈欠。在这些研究中，大鼠均未表现出任何与D2或混合D1/D2受体刺激相关的运动亢进迹象或任何刻板反应。这些数据表明，7-OH-DPAT在NAC中引发的运动减少可能是由D3受体介导的，这与D2多巴胺受体不同。我们讨论了我们观察到的行为效应是由D3自身受体介导的可能性。