Osborne A R, Refinetti R
Department of Psychology, College of William & Mary, Williamsburg, Virginia 23187, USA.
Neuroreport. 1995 Nov 13;6(16):2187-92. doi: 10.1097/00001756-199511000-00021.
The effects of electrolytic and neurotoxic lesions of the suprachiasmatic nucleus (SCN) and preoptic area (POA) of the anterior hypothalamus were studied by temperature telemetry in the golden hamster (Mesocricetus auratus) examined under two ambient temperature conditions: 24 degrees C and 6 degrees C. Although attempted lesions with microinjections of ibotenic acid proved unsuccessful, electrolytic lesions of the SCN eliminated the circadian rhythm of body temperature (CRT), indicating an active role of this nucleus in the establishment of the CRT. Electrolytic lesions of the POA, but not of the SCN, resulted in an increased amplitude of the CRT at both 24 degrees C and 6 degrees C, with the lower ambient temperature enhancing this amplitude change to a greater extent. These results suggest that the POA and the SCN are independently responsible for the homeostatic and circadian regulation of body temperature, respectively. The increased amplitude of the CRT after POA lesions raises the possibility that the thermoregulatory system may oppose rather than defend the circadian control of body temperature in normal animals, which is consistent with several recent behavioral findings.
通过温度遥测技术，在24摄氏度和6摄氏度这两种环境温度条件下，对金黄仓鼠（Mesocricetus auratus）下丘脑视交叉上核（SCN）和视前区（POA）进行电解损伤和神经毒性损伤的影响进行了研究。尽管通过注射鹅膏蕈氨酸进行的损伤尝试未成功，但SCN的电解损伤消除了体温昼夜节律（CRT），表明该核在CRT的建立中发挥着积极作用。POA而非SCN的电解损伤导致在24摄氏度和6摄氏度时CRT的振幅增加，较低的环境温度在更大程度上增强了这种振幅变化。这些结果表明，POA和SCN分别独立负责体温的稳态调节和昼夜调节。POA损伤后CRT振幅增加，这增加了一种可能性，即体温调节系统在正常动物中可能对抗而非维护体温的昼夜控制，这与最近的一些行为学研究结果一致。
