[具有修饰极性基团的类视黄醇的合成及其抗肿瘤活性。报告一]
[Synthesis of retinoids with a modified polar group and their antitumor activity. Report I].
作者信息
Deriabina E L, Khodonov A A, Cherevataia G V, Kirillova Iu G, Shvets V I, Kostanian I A, Astapova M V, Dranitsyna S M, Starovoĭtova E V
出版信息
Bioorg Khim. 1995 Dec;21(12):941-9.
PMID:8602891
Abstract
Several retinoids with modified polar group were synthesized. Biological screening using HL-60 promyelocyte leukemia cells showed that the free carboxyl in the retinoid molecules is not the only group responsible for exhibiting the differentiating activity.
摘要
合成了几种带有修饰极性基团的类视黄醇。使用HL-60早幼粒细胞白血病细胞进行的生物学筛选表明，类视黄醇分子中的游离羧基并非展现分化活性的唯一基团。
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